FLASH Antibody

Background:FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild t*e of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity. Studies of FLASH protein suggested that this protein may be a component of the death inducing signaling complex that includes Fas receptor, Fas binding adapter FADD, and caspase 8, and plays a regulatory role in Fas mediated apoptosis.

Description:Rabbit polyclonal to FLASH

Immunogen:KLH conjugated synthetic peptide derived from FLASH

Specificity:·Reacts with Human, Mouse and Rat.

·Isot*e: IgG

Application:·Western blotting: 1/100-500. Predicted Mol wt: 220 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;

·Immunocytochemistry: 1/100-500;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.

企业名：虞华芳

类型：经销商

电话： 086 0511 86909515

联系人：虞华芳

地址：江苏中国 江苏 丹阳市 丹金路3号